I denti ingialliscono e si macchiano, sono più soggetti all'accumulo di placca e carie. Le gengive, a causa dell'aumento di placca e carie e della diminuzione del contenuto di ossigeno nella bocca, sono più soggette a infezioni batteriche che possono dare origine a parodontite, nota anche occur piorrea.
Questi prodotti contengono o sali di nicotina o, dall'inizio del 2021, nicotina sintetica, i cui effetti sulla salute sono completamente sconosciuti. Contengono inoltre numerosi altri composti volatili come gli idrocarburi aromatici policiclici.
Nel caso specifico dell'alitosi da fumo, è consigliabile lavarsi denti e lingua anche subito dopo aver fumato, così da ridurre notevolmente l'odore di fumo in bocca e ripristinare un alito gradevole.
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Due studi americani mettono in guardia sulle e-cig, quando a fumarle sono adolescenti: sarebbero associate a un aumento del rischio di passare al fumo tradizionale e di sviluppare disturbi respiratori.
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